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What Pain Medication is Safe For Kidneys?

What Pain Medication is Safe For Kidneys?


If you’re wondering what pain medication is safe for your kidneys, you’ve come to the right place.

You’ll find information about COVID-19, Fentanyl, Hydromorphone, and Gabapentin.

Read on to learn more about each of these drugs.

Listed below are the pros and cons of each. If you’re worried about any of these medications, talk to your doctor.

COVID-19 The safety of COVID-19 for kidney transplantation is still debated.

While the vaccine itself is generally safe, people taking immunosuppressive medications may not get the same degree of protection or antibody immunity from it.

For this reason, the CDC recommends an additional dose of the COVID-19 vaccine at least 28 days after the first dose.

Although the vaccine is safe for kidney transplant recipients, you should still talk to your doctor if you have any concerns.

In autopsy studies, COVID-19-induced AKI rates decreased significantly. However, there is little available data on temporal trends.

One study noted a drop in AKI rates during the pandemic. COVID-19-associated AKI may be due to hemodynamic changes, cytokine release, or direct cytotoxicity.

In addition to these potential adverse effects, COVID-19 was associated with increased mortality in patients who developed preexisting kidney disorders.




Fentanyl is a synthetic opioid that has a rapid onset, short duration, and minimal metabolites. It is used in the treatment of opioid-induced pain and as a sedative of choice in critically ill patients.

However, fentanyl has several adverse side effects, including serotonin syndrome and renal dysfunction.

If you are wondering whether fentanyl is safe for kidneys, you need to know the facts about this medication. The most important factor to consider is whether the substance is safe for the kidneys.

A recent study showed that opioids are safe for patients with CKD and kidney disease.

However, in a randomized controlled trial, only fentanyl and buprenorphine were as effective in patients with CKD. Moreover, fentanyl is poorly dialyzed and does not have active metabolites.




The safety of hydromorphone for the kidneys has been studied extensively. Hydromorphone has low molecular weight and low volume of distribution.

The pharmacokinetics of hydromorphone have also been studied. According to Zheng et al., hydromorphone is metabolized to a minor inactive product, hydromorphone 3 glucuronide.

The metabolite hydromorphone-g has a low affinity for the human protein. It is dialyzable, and its plasma concentrations are reduced to 40% of the predialysis level.

However, there are concerns regarding the safety of hydromorphone and opiate use in patients with renal impairment.

Although high doses of hydromorphone can cause neurotoxic effects, there is no consensus among experts. However, clinicians can safely use hydromorphone in patients with mild to moderate renal impairment.

If there is any doubt about the safety of hydromorphone in patients with renal failure, it is suggested that clinicians use hydromorphone in a dose-dependent manner and monitor closely the patient.




The safety of gabapentin for chronic kidney disease remains debated. While gabapentin is generally safe, the medication has a range of clinical considerations, including the risk of rhabdomyolysis and acute kidney injury.

To make sure that gabapentin is safe for kidneys, pharmacists should be aware of the patient’s kidney function.

Patients with impaired kidney function are at greater risk for serious drug interactions, including fatalities. One case reported in a study included two cases of myoclonus associated with gabapentin toxicity.

Both cases were diagnosed with end-stage PD and HD and underwent surgery. After the withdrawal of gabapentin, both patients recovered from their symptoms.

However, in one patient, gabapentin treatment was discontinued due to myoclonus, and a higher creatinine level was found.

In a subsequent case, a 53-year-old man presented with a fever, right groin pain, and a purulent discharge from a prior vascular cannulation site.

Lidocaine patches


lidocaine patches

The lidocaine patches contain lidocaine, a type of anesthetic. While the pain relief is quick, the patch contains some side effects that are not desirable for your kidneys.

The following are some of these side effects. You may experience blisters, redness, swelling, or changes in skin color.

Depending on the patch, you may experience a burning, itching, or itching sensation. If these effects persist, you may need to apply another patch or wait until the irritation subsides.

The concentration of lidocaine in the blood is related to the amount of surface area and duration of the application.

For example, three LIDODERM patches were applied to the back of normal volunteers for 12 hours.

Blood samples were taken during application, removal, and 12 hours after the last patch was removed.

In addition to the safety risks, the drug’s toxicity is also limited. However, some people may experience methemoglobinemia, a serious condition characterized by decreased red blood cell production.





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