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What Causes Diabetes in Fat People?

Last Updated on June 21, 2022 by Nurse Vicky

What Causes Diabetes in Fat People?


What causes diabetes in fat people? Several factors are implicated in the development of diabetes in people who are obese, including genetics, obesity, insulin resistance, and the stress hormone cortisol.

But the real culprits are far more complex.

Here is a look at some of the key factors involved in the development of type 2 diabetes in fat people.

Using the following information to help prevent diabetes, and control its consequences, you can begin a healthy lifestyle and lose weight.



Obesity can increase the risk of developing type 2 diabetes, also known as insulin-resistant diabetes.

This disease is characterized by persistently high blood sugar levels.

Overweight individuals are 80 times more likely to develop diabetes than those who are thin.

Type 2 diabetes occurs when the pancreas is unable to properly process glucose in the blood, which causes inflammation and the release of cytokines that block the insulin receptors. 

Type 2 diabetes is an impaired metabolic process of sugar and fats in the blood.

It can be caused by obesity or by a family history of diabetes.

Obese individuals are also at risk of developing diabetes, especially women who have given birth to a baby weighing more than nine pounds.

Several other factors increase the risk of developing type 2 diabetes. Fortunately, there are many treatments available to treat the condition.


screenshot 2022 06 17 at 14.15.25

Researchers have wondered whether genes are involved in the development of obesity.

The human genome contains instructions on how to respond to the environment, and the distribution of body fat is one of the most obvious evidence.

The Mendelian randomization method was used to study the differences between individuals, including fat people and lean people, and found that twelve diseases were associated with favorable adiposity.

Nine diseases, however, were not linked to genetics but were associated with other factors, including obesity. Despite these findings, obesity remains a significant health risk regardless of body fat distribution.

For example, people who are obese or diabetic also face increased risks for adult-onset asthma, psoriasis, and gallstones.

While certain genes are responsible for the development of type 1 diabetes, it is not necessarily a guarantee. People who have the HLA-DR3 gene are at increased risk for the development of type 1 diabetes.

However, this gene also affects type 2 diabetes, which is characterized by the progressive destruction of beta cells in the pancreas.

Because blood sugar levels are elevated due to insufficient insulin, type 2 diabetes is caused by the progressive loss of beta cells.

Insulin resistance


insulin resistance

Type 2 diabetes is a complex disease involving the body’s insulin receptors and excessive weight.

Both are associated with weight gain. While insulin resistance can occur in people of any weight, the role of insulin is most evident in obese individuals.

Insulin, a hormone that controls the levels of glucose in the bloodstream, plays a pivotal role in regulating blood sugar.

But high insulin levels can cause weight gain as well.

While the development of diabetes in obese individuals can be frustrating, fortunately, the good news is that there are ways to combat insulin resistance.

Exercise and diet can improve insulin sensitivity. In addition to lifestyle changes, prescription medicines and insulin are also available.

Ultimately, your doctor will determine if insulin resistance can be treated with diet and exercise.

If the condition is uncontrolled, you may require medication.

However, insulin-sensitizing medications are the best way to address this type of diabetes.




Researchers have recently proposed that high levels of cortisol are responsible for the increased risk of diabetes.

The researchers studied 369 subjects from eight countries who had similar BMI and age, a high proportion of which were Caucasian.

They also looked at their waist circumference and insulin levels.

The results showed a statistically significant association between high levels of cortisol and insulin, triglycerides, and diabetes risk in men.

The study involved 16 subjects: nine men and seven women, with a mean age of 34.6 SD 7 years.

Six patients had impaired glucose tolerance and their glucocorticoid receptors were measured in all of them. Researchers also found that cortisol and insulin secretion levels were similar in those without diabetes or metabolic syndrome.

Thus, the study suggests that cortisol may play a role in diabetes and obesity.

Diet high in trans and saturated fats

diet high in trans and saturated fats

Studies have shown that a diet high in trans and saturated fatty acids may lead to type 2 diabetes.

Those with diabetes are often obese and resistant to insulin, a hormone that removes glucose from the blood and stores it for energy.

However, it is not clear whether the two factors are directly connected.

Researchers from the University of North Carolina at Chapel Hill School of Medicine have suggested that obesity and diabetes go hand in hand.

Saturated and trans fatty acids activate immune cells that are responsible for producing an inflammatory protein.

Saturated fats are found naturally in a variety of foods. Meat, dairy products, and cocoa butter contain saturated fats.

Fried foods are typically made with commercial shortening.

Deep-frying fats are hydrogenated and contain trans and saturated fats.

To cut the amount of trans and saturated fats in your diet, keep a food diary.

This will help you monitor what foods you eat and what is unhealthy.

Immune system

immune system

The connection between obesity and illness has been well documented, and researchers are now looking at how fat tissue contributes to metabolic disease.

In mouse studies, they have found that fat tissue contains increased levels of macrophages, immune cells that gobble up and break down foreign material and help other immune cells determine whether something is a threat.

Lindsey Muir, research assistant professor at the University of California, San Diego, and colleagues report their findings in Diabetes Care.

Type 2 diabetes is a metabolic disorder that occurs when the body’s chemical processes fail to process the sugar it produces.

However, new research indicates that the disease may be an autoimmune disease, which could lead to the development of new treatments and therapies.

Until then, medical treatment for type 2 diabetes relies on two pillars:

diet and exercise, and oral medications that increase the body’s ability to utilize insulin or lower the production of glucose.


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