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 Unraveling the Mystery: 5 Key Factors Contributing to the Prevalence of Malaria in Africa

Last Updated on May 23, 2023 by Nurse Vicky

 Unraveling the Mystery: 5 Key Factors Contributing to the Prevalence of Malaria in Africa


Malaria, a life-threatening disease caused by the Plasmodium parasite, remains a significant health concern in Africa. Despite global efforts to combat this infectious disease, it continues to exert a heavy toll on the continent’s population.

This comprehensive article aims to delve into the key factors that contribute to the high prevalence of malaria in Africa. By understanding these factors, we can better address the challenges and work towards effective prevention and control measures.

 Geographic Factors and Climate


Africa’s geographical features, such as its vast landscapes, dense forests, and numerous bodies of water, create favorable conditions for mosquito breeding and the spread of malaria.

The Anopheles mosquito, responsible for transmitting malaria, thrives in warm and humid environments. Additionally, the prolonged rainy seasons in many African regions contribute to the proliferation of mosquito populations, leading to increased malaria transmission rates.

 Socioeconomic Challenges


Socioeconomic factors play a significant role in the prevalence of malaria in Africa. Poverty, limited access to healthcare services, and inadequate infrastructure contribute to the disease’s persistence.

Impoverished communities often lack essential resources, such as insecticide-treated bed nets, insecticides, and antimalarial medications. Additionally, the lack of proper sanitation and drainage systems creates breeding grounds for mosquitoes, further exacerbating the problem.

 Weak Healthcare Systems and Limited Resources


Insufficient healthcare infrastructure and resources pose significant challenges to malaria control efforts in Africa. Many healthcare systems in the region are burdened with limited funding, a shortage of skilled healthcare professionals, and inadequate diagnostic and treatment facilities.

These shortcomings hinder prompt and accurate diagnosis, timely treatment, and effective surveillance, allowing malaria to persist and spread within communities.

 High Mosquito Vector Density


The Anopheles mosquito, the primary vector of malaria, exhibits high population densities in many African regions. The ability of these mosquitoes to adapt and thrive in various ecological settings contributes to the ongoing transmission of malaria. Their presence in both urban and rural areas poses a constant threat to the population, making it difficult to eradicate the disease entirely.

 Resistance to Antimalarial Drugs and Insecticides


The emergence and spread of drug-resistant strains of the malaria parasite, particularly Plasmodium falciparum, present a significant challenge in malaria control efforts. Substandard or counterfeit antimalarial drugs further contribute to the development of drug resistance.

Similarly, mosquito populations have shown resistance to commonly used insecticides, reducing the effectiveness of vector control measures. These factors hinder the success of treatment and prevention strategies, leading to higher malaria prevalence rates.

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Climate change


Whether or not climate change will lead to a decrease in the prevalence of malaria in Africa is unclear, but a recent study has provided some insight. In fact, the worst-case scenario shows malaria cases in Eastern and Southern Africa could triple by 2080.

The worst-case scenario also predicts shorter season lengths. Malaria epidemics in Africa are most likely to occur during the rainy season, which is predicted to be less frequent during the warmer months.

The report highlights the fact that African countries are currently underprepared to cope with the consequences of climate change. While malaria is a prevalent disease in sub-Saharan Africa, it costs millions of dollars each year in household and public health expenditures.

Unfortunately, most West African countries have yet to fully adapt to climate change’s adverse effects. Moreover, there is still no concrete evidence of a direct relationship between climate and health.

Declining health services


The death toll from malaria has been estimated at one million in Africa each year since the 1950s, but these estimates lack a strong methodological basis and empirical evidence.

They rely on crude empirical epidemiological estimates based on age and malaria transmission rates. A study by the University of Texas-San Antonio has shown that distributing insecticide-treated bednets reduces malaria mortality by 60 percent in a country like The Gambia.

The decline of health services in Africa poses an additional problem. There are no universal vital registration systems in Sub-Saharan Africa, and the country’s national systems are incomplete or unreliable.

In many countries, most deaths occur outside of the formal health system, so defining malaria-specific mortality has proven difficult. To combat this problem, epidemiologists have set up demographic surveillance systems to track migration, births, and deaths.

Declining drug resistance

Although the rise of artemisinin-resistant malaria is alarming, it may not be a major threat to African countries. In fact, artemisinin resistance is still relatively low in Africa, but it may be an issue for countries in Southeast Asia, where the threat is greater.

In addition, the region is vulnerable to an escalation of drug resistance in any one drug, so it could take decades to eradicate this disease. In 2009, artemisinin resistance was first observed along the Thai-Cambodia border, where one component failed to clear parasites fast, leaving the partner drug to pick up the slack.

Now, resistance to multiple drugs is widespread in the Greater Mekong Subregion. With resistance spreading to other regions, scientists fear that it will spread to Africa, where malaria is more widespread.

Pregnant women’s high risk of infection


Pregnant women are particularly vulnerable to malaria infection because their immunity is lowered during pregnancy, putting them at risk of sickness and death.

In addition to maternal malaria, women who contract the disease during pregnancy are at a much greater risk of miscarriage, stillbirth, premature delivery, and low birth weight. Malaria is also a major cause of child mortality and affects every pregnant woman in the African country of Cote d’Ivoire.

Vaccination against malaria during pregnancy is essential, as it reduces the risk of congenital disabilities and low birth weight. Malaria prevention programs should also target young children because malaria infection during pregnancy can be harmful to both the mother and her unborn child.

In sub-Saharan Africa, malaria deaths are the third leading cause of death in women of reproductive age, and more than 400,000 of these deaths occur in babies born to pregnant women. Vaccination and treatment programs are crucial, but unfortunately, pregnant women are not included in clinical trials.

Frequently Asked Questions 

 What are the most common symptoms of malaria?


Malaria manifests through a variety of symptoms, which can range from mild to severe. The most common symptoms of malaria include:

  1. Fever: Fever is one of the primary indicators of malaria. It may present as intermittent high fever, often accompanied by chills and sweating. The fever pattern may follow a cyclical pattern, with symptoms recurring every 48 to 72 hours, depending on the type of malaria parasite.
  2. Headaches: Headaches are commonly associated with malaria. They can range from mild to severe and are often persistent.
  3. Fatigue: Fatigue and a general feeling of weakness are common in malaria cases. The person may experience excessive tiredness, lack of energy, and a reduced ability to carry out daily activities.
  4. Muscle and Joint Pain: Malaria can cause muscle and joint pain, also known as myalgia and arthralgia, respectively. These pains can be widespread and affect various parts of the body.
  5. Nausea and Vomiting: Malaria infections often lead to gastrointestinal symptoms such as nausea, vomiting, and loss of appetite. These symptoms may contribute to dehydration and further weakness.
  6. Sweating: Profuse sweating, especially during fever episodes, is a common symptom of malaria. Sweating is often accompanied by a feeling of coldness or chills.
  7. Abdominal Pain: Some individuals with malaria may experience abdominal pain, which can range from mild discomfort to severe cramping. This symptom is more common in cases of severe malaria.
  8. Cough and Respiratory Symptoms: In certain types of malaria, respiratory symptoms such as a cough, difficulty breathing, or chest pain may occur. These symptoms are more prevalent in severe cases.

It is important to note that the symptoms of malaria can vary depending on the individual and the type of malaria parasite involved. Additionally, some individuals, particularly those with partial immunity or repeated exposure to malaria, may exhibit milder symptoms or even be asymptomatic carriers. If you suspect malaria or experience any of the aforementioned symptoms, it is crucial to seek medical attention promptly for proper diagnosis and treatment.

Remember, early diagnosis and appropriate treatment are essential in managing malaria and preventing severe complications.

How is malaria diagnosed?


Malaria diagnosis involves several methods to detect the presence of malaria parasites in the blood. Prompt and accurate diagnosis is crucial for initiating timely treatment and preventing complications. The following are the commonly used diagnostic techniques for malaria:

  1. Microscopic Examination of Blood Smears: Microscopic examination of blood smears remains the gold standard for malaria diagnosis. A drop of blood is obtained from the patient and spread on a glass slide. The slide is then stained with specific dyes to visualize the malaria parasites under a microscope. Skilled laboratory technicians examine the slides to identify and differentiate the malaria parasite species.
  2. Rapid Diagnostic Tests (RDTs): Rapid diagnostic tests are widely used in areas with limited access to microscopy facilities. RDTs detect specific malaria antigens in the blood sample. The test involves placing a small amount of blood on a test strip or cassette, which contains antibodies that react with malaria antigens. The appearance of colored lines indicates the presence of malaria parasites and their species.
  3. Molecular Methods (Polymerase Chain Reaction, PCR): Molecular techniques like PCR are highly sensitive and specific for malaria diagnosis. PCR detects the genetic material (DNA/RNA) of the malaria parasite. This method can identify even low parasite levels and differentiate between different species of malaria parasites. However, PCR testing requires specialized laboratory equipment and trained personnel.
  4. Serological Tests: Serological tests detect antibodies produced by the immune system in response to malaria infection. These tests are helpful in assessing past exposure to malaria parasites but are not suitable for diagnosing active infections. Serological tests are often used for surveillance studies and assessing the prevalence of malaria in a particular population.

It is important to note that the choice of diagnostic method may depend on various factors, including the availability of resources, infrastructure, and the expertise of healthcare providers. In some cases, a combination of diagnostic methods may be used to ensure accurate results.

If you suspect malaria or experience symptoms associated with the disease, it is essential to seek medical attention promptly. Healthcare professionals will perform the necessary diagnostic tests to confirm the presence of malaria parasites and determine the appropriate treatment regimen based on the parasite species and the patient’s condition. Remember, early diagnosis and timely treatment play a vital role in managing malaria effectively and reducing its impact on individuals and communities.

What is the difference between uncomplicated and severe malaria?


Malaria can range from uncomplicated, where the infection is mild and manageable, to severe, where the disease poses a significant threat to a person’s life. The distinction between uncomplicated and severe malaria is based on the severity of symptoms and the potential for life-threatening complications. Here are the key differences:

Uncomplicated Malaria: Uncomplicated malaria refers to a milder form of the disease that can be managed with appropriate treatment. The common characteristics of uncomplicated malaria include:

  1. Symptoms: Individuals with uncomplicated malaria typically experience symptoms such as fever, chills, headaches, muscle pain, fatigue, and nausea. These symptoms may vary in intensity but do not involve severe complications.
  2. No Organ Dysfunction: Uncomplicated malaria does not lead to major dysfunction or failure of vital organs such as the brain, kidneys, liver, or lungs. The infection is generally confined to the bloodstream and does not cause widespread damage.
  3. Ability to Take Oral Medications: Patients with uncomplicated malaria can usually take oral antimalarial medications without difficulty, facilitating treatment and recovery.
  4. Faster Recovery: With appropriate treatment, individuals with uncomplicated malaria generally recover within a relatively short period, typically a few days to a couple of weeks.

Severe Malaria: Severe malaria is a life-threatening condition that requires urgent medical intervention. It is associated with severe complications and can lead to organ failure and death if not promptly treated. The key characteristics of severe malaria include:

  1. Severe Symptoms: Severe malaria is marked by intense symptoms such as high fever, altered consciousness, seizures, severe headache, severe anemia, respiratory distress, and jaundice. These symptoms may indicate the involvement of vital organs.
  2. Organ Dysfunction: Severe malaria can lead to dysfunction or failure of vital organs, including the brain (cerebral malaria), kidneys, liver, lungs, and the blood coagulation system. These complications significantly increase the risk of morbidity and mortality.
  3. Inability to Take Oral Medications: Patients with severe malaria may be unable to tolerate oral medications due to impaired consciousness, vomiting, or other complications. Intravenous administration of antimalarial drugs is often required.
  4. Prolonged Recovery: Recovery from severe malaria is a more protracted process compared to uncomplicated cases. It may take weeks or even months for the individual to fully regain health, and some residual effects can persist.

Prompt diagnosis and immediate treatment are crucial in preventing uncomplicated malaria from progressing to severe malaria. If you suspect malaria or experience severe symptoms, it is essential to seek urgent medical care.

Healthcare professionals will assess the severity of the disease, initiate appropriate treatment, and closely monitor the patient to prevent complications and ensure a favorable outcome. Remember, severe malaria requires specialized medical attention, and timely intervention can be lifesaving.


Are there any vaccines available for malaria?


Currently, there is a vaccine available for malaria called RTS, S/AS01, commercially known as Mosquirix. However, it is important to note that this vaccine does not provide complete protection against malaria and its efficacy varies depending on factors such as age and geographical location. Here is some key information about the malaria vaccine:

  1. RTS, S/AS01 (Mosquirix): Mosquirix is the most advanced malaria vaccine currently available. It was developed by GlaxoSmithKline (GSK) in partnership with the PATH Malaria Vaccine Initiative. The vaccine targets Plasmodium falciparum, the most common and deadly malaria parasite in Africa.
  2. Vaccine Efficacy: Clinical trials have shown that the RTS, S/AS01 vaccine provides partial protection against malaria in young children. According to the World Health Organization (WHO), the vaccine has demonstrated an average efficacy of around 30-50% in preventing severe malaria cases and reducing overall malaria episodes in vaccinated children.
  3. Vaccine Administration: The vaccine is administered in multiple doses through an injection. In the recommended schedule, children receive four doses: the first dose between 5 and 17 months of age, followed by three additional doses over the course of several months. The vaccine is not yet widely available and is primarily administered through pilot implementation programs.
  4. Limitations: While the malaria vaccine is a significant step forward in malaria prevention, it has certain limitations. The duration of protection provided by the vaccine is limited, and its efficacy decreases over time. Additionally, the vaccine does not protect against all malaria parasite species, as it specifically targets Plasmodium falciparum.
  5. Complementary Measures: Vaccination should be considered as a part of comprehensive malaria control strategies. It is important to continue implementing other preventive measures, such as the use of insecticide-treated bed nets, indoor residual spraying, and prompt diagnosis and treatment of malaria cases.
  6. Ongoing Research: Various research institutions and organizations continue to explore and develop new malaria vaccine candidates. These efforts aim to improve vaccine efficacy, expand coverage to other malaria parasite species, and provide longer-lasting protection. However, the development of an ideal malaria vaccine that provides complete and long-term immunity remains a complex challenge.

It is essential to consult with healthcare professionals and local health authorities for the latest information on the availability and recommendations regarding malaria vaccination.

While the current vaccine has shown some efficacy, it is important to combine vaccination with other preventive measures to effectively reduce the burden of malaria and protect against the disease.

Remember, even with the availability of a vaccine, continued efforts in vector control, early diagnosis, and access to prompt treatment remain crucial in the fight against malaria.

What are the most effective methods for preventing malaria?


Preventing malaria primarily involves a combination of personal protective measures and community-based interventions. Here are the most effective methods for preventing malaria:

  1. Use of Insecticide-Treated Bed Nets: Sleeping under insecticide-treated bed nets (ITNs) is one of the most effective strategies for preventing malaria. These nets create a physical barrier that keeps mosquitoes away and are treated with insecticides that kill or repel mosquitoes. ITNs provide protection not only during nighttime but also when individuals take daytime naps.
  2. Indoor Residual Spraying (IRS): Indoor residual spraying is a targeted approach where insecticides are sprayed on the walls and surfaces inside houses, particularly in areas with high malaria transmission. The insecticides kill mosquitoes that come into contact with the treated surfaces, reducing their population and interrupting disease transmission.
  3. Personal Protective Measures: When in malaria-endemic areas, individuals should take personal protective measures to reduce mosquito bites. This includes wearing long-sleeved shirts, long pants, and socks to minimize exposed skin. Applying insect repellents to exposed areas of the body can also be effective.
  4. Chemoprophylaxis: For travelers visiting areas with high malaria transmission, taking antimalarial medications as prescribed by healthcare professionals is essential. Chemoprophylaxis aims to prevent the development of malaria infection in individuals exposed to the malaria parasite.
  5. Environmental Management: Eliminating or managing mosquito breeding sites plays a crucial role in malaria prevention. This includes clearing stagnant water, proper disposal of waste, and improving drainage systems to minimize standing water where mosquitoes breed.
  6. Community-Based Interventions: Community engagement is vital in malaria control. This involves raising awareness about malaria prevention, encouraging prompt diagnosis and treatment of malaria cases, and fostering community participation in vector control activities, such as cleaning the environment and using preventive measures collectively.
  7. Early Diagnosis and Prompt Treatment: Timely diagnosis and appropriate treatment of malaria cases are essential for preventing severe disease and further transmission. Seeking medical attention promptly when experiencing malaria symptoms and completing the full course of antimalarial treatment as prescribed contribute to effective disease management.

It is important to note that no single method provides absolute protection against malaria. Combining several preventive strategies in an integrated approach yields the best results in reducing malaria transmission and burden.

Additionally, the choice of preventive measures may vary depending on factors such as local malaria epidemiology, individual risk factors, and the availability of resources. Therefore, it is advisable to consult with healthcare professionals and local health authorities for specific recommendations on malaria prevention in a particular region or setting.

Remember, consistent adherence to preventive measures, along with community involvement and robust healthcare systems, plays a crucial role in controlling and eventually eliminating malaria.



Malaria’s prevalence in Africa is influenced by a combination of complex factors, ranging from geographical and climatic conditions to socioeconomic challenges and healthcare system limitations. To combat this devastating disease, concerted efforts are required on multiple fronts.

Strengthening healthcare systems, improving access to essential resources, implementing effective vector control measures, and promoting education and awareness about malaria prevention are vital steps toward reducing its burden. By addressing these factors comprehensively, we can make significant strides in the fight against malaria in Africa


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